Serveur d'exploration sur la détoxication des champignons

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

The transcription factor NemR is an electrophile-sensing regulator important for the detoxification of reactive electrophiles in Acinetobacter nosocomialis.

Identifieur interne : 000291 ( Main/Exploration ); précédent : 000290; suivant : 000292

The transcription factor NemR is an electrophile-sensing regulator important for the detoxification of reactive electrophiles in Acinetobacter nosocomialis.

Auteurs : Bindu Subhadra [Corée du Sud] ; Surya Surendran [Corée du Sud] ; Dong Ho Kim [Corée du Sud] ; Kyungho Woo [Corée du Sud] ; Man Hwan Oh [Corée du Sud] ; Chul Hee Choi [Corée du Sud]

Source :

RBID : pubmed:30797834

Descripteurs français

English descriptors

Abstract

NemR is an electrophile-sensing regulator which controls two enzymes required for the detoxification of reactive electrophiles: N-ethylmaleimide (NEM) reductase and glyoxalase I in Escherichia coli. Both enzymes are essential for bacterial survival in the presence of toxic reactive electrophiles, such as N-ethylmaleimide and methyl glyoxal. Here, we report the identification and characterization of NemR from Acinetobacter nosocomialis, a nosocomial pathogen. We confirmed that nemR and the nemA gene which encodes N-ethylmaleimide reductase form a single operon, which is in accordance with the reports from E. coli. Bioinformatic analysis revealed the presence of an NemR binding motif in the promoter regions of nemRA operon and gloA (encoding glyoxalase I) and the binding was confirmed by gel mobility shift assay. The deletion of nemR resulted in increased biofilm/pellicle formation in A. nosocomialis. mRNA expression analysis revealed that NemR acts as a repressor of the nemRA operon and gloA, and that the repressor function is inactivated by the addition of toxic Cys modification agents, contributing to bacterial survival. In addition, it was demonstrated that the nemRA operon is positively regulated by the quorum sensing regulator, AnoR and the operon plays a role in biofilm/pellicle formation in A. nosocomialis.

DOI: 10.1016/j.resmic.2019.02.001
PubMed: 30797834


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">The transcription factor NemR is an electrophile-sensing regulator important for the detoxification of reactive electrophiles in Acinetobacter nosocomialis.</title>
<author>
<name sortKey="Subhadra, Bindu" sort="Subhadra, Bindu" uniqKey="Subhadra B" first="Bindu" last="Subhadra">Bindu Subhadra</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: bindu.subhadra@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Surendran, Surya" sort="Surendran, Surya" uniqKey="Surendran S" first="Surya" last="Surendran">Surya Surendran</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: tankz93@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kim, Dong Ho" sort="Kim, Dong Ho" uniqKey="Kim D" first="Dong Ho" last="Kim">Dong Ho Kim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: casiopea1208@naver.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Woo, Kyungho" sort="Woo, Kyungho" uniqKey="Woo K" first="Kyungho" last="Woo">Kyungho Woo</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: khwoo1991@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Oh, Man Hwan" sort="Oh, Man Hwan" uniqKey="Oh M" first="Man Hwan" last="Oh">Man Hwan Oh</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Nanobiomedical Science, Dankook University, Cheonan, 31116, South Korea. Electronic address: yy1091@dankook.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Nanobiomedical Science, Dankook University, Cheonan, 31116</wicri:regionArea>
<wicri:noRegion>31116</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Choi, Chul Hee" sort="Choi, Chul Hee" uniqKey="Choi C" first="Chul Hee" last="Choi">Chul Hee Choi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: choich@cnu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2019">2019 Apr - May</date>
<idno type="RBID">pubmed:30797834</idno>
<idno type="pmid">30797834</idno>
<idno type="doi">10.1016/j.resmic.2019.02.001</idno>
<idno type="wicri:Area/Main/Corpus">000544</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000544</idno>
<idno type="wicri:Area/Main/Curation">000544</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000544</idno>
<idno type="wicri:Area/Main/Exploration">000544</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">The transcription factor NemR is an electrophile-sensing regulator important for the detoxification of reactive electrophiles in Acinetobacter nosocomialis.</title>
<author>
<name sortKey="Subhadra, Bindu" sort="Subhadra, Bindu" uniqKey="Subhadra B" first="Bindu" last="Subhadra">Bindu Subhadra</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: bindu.subhadra@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Surendran, Surya" sort="Surendran, Surya" uniqKey="Surendran S" first="Surya" last="Surendran">Surya Surendran</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: tankz93@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kim, Dong Ho" sort="Kim, Dong Ho" uniqKey="Kim D" first="Dong Ho" last="Kim">Dong Ho Kim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: casiopea1208@naver.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Woo, Kyungho" sort="Woo, Kyungho" uniqKey="Woo K" first="Kyungho" last="Woo">Kyungho Woo</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: khwoo1991@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Oh, Man Hwan" sort="Oh, Man Hwan" uniqKey="Oh M" first="Man Hwan" last="Oh">Man Hwan Oh</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Nanobiomedical Science, Dankook University, Cheonan, 31116, South Korea. Electronic address: yy1091@dankook.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Nanobiomedical Science, Dankook University, Cheonan, 31116</wicri:regionArea>
<wicri:noRegion>31116</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Choi, Chul Hee" sort="Choi, Chul Hee" uniqKey="Choi C" first="Chul Hee" last="Choi">Chul Hee Choi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: choich@cnu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015</wicri:regionArea>
<wicri:noRegion>35015</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Research in microbiology</title>
<idno type="eISSN">1769-7123</idno>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Acinetobacter (drug effects)</term>
<term>Acinetobacter (enzymology)</term>
<term>Acinetobacter (genetics)</term>
<term>Antioxidants (metabolism)</term>
<term>Bacterial Proteins (metabolism)</term>
<term>DNA, Bacterial (metabolism)</term>
<term>Electrophoretic Mobility Shift Assay (MeSH)</term>
<term>Ethylmaleimide (toxicity)</term>
<term>Gene Deletion (MeSH)</term>
<term>Gene Expression Profiling (MeSH)</term>
<term>Gene Expression Regulation, Bacterial (MeSH)</term>
<term>Gene Order (MeSH)</term>
<term>Glyoxal (toxicity)</term>
<term>Metabolic Detoxication, Phase I (MeSH)</term>
<term>Operon (MeSH)</term>
<term>Protein Binding (MeSH)</term>
<term>Repressor Proteins (genetics)</term>
<term>Repressor Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>ADN bactérien (métabolisme)</term>
<term>Acinetobacter (effets des médicaments et des substances chimiques)</term>
<term>Acinetobacter (enzymologie)</term>
<term>Acinetobacter (génétique)</term>
<term>Analyse de profil d'expression de gènes (MeSH)</term>
<term>Antioxydants (métabolisme)</term>
<term>Délétion de gène (MeSH)</term>
<term>Détoxication de phase I (MeSH)</term>
<term>Glyoxal (toxicité)</term>
<term>Liaison aux protéines (MeSH)</term>
<term>N-Éthyl-maléimide (toxicité)</term>
<term>Opéron (MeSH)</term>
<term>Ordre des gènes (MeSH)</term>
<term>Protéines bactériennes (métabolisme)</term>
<term>Protéines de répression (génétique)</term>
<term>Protéines de répression (métabolisme)</term>
<term>Régulation de l'expression des gènes bactériens (MeSH)</term>
<term>Test de retard de migration électrophorétique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Repressor Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Antioxidants</term>
<term>Bacterial Proteins</term>
<term>DNA, Bacterial</term>
<term>Repressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Acinetobacter</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr">
<term>Acinetobacter</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr">
<term>Acinetobacter</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en">
<term>Acinetobacter</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Acinetobacter</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Acinetobacter</term>
<term>Protéines de répression</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>ADN bactérien</term>
<term>Antioxydants</term>
<term>Protéines bactériennes</term>
<term>Protéines de répression</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en">
<term>Ethylmaleimide</term>
<term>Glyoxal</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr">
<term>Glyoxal</term>
<term>N-Éthyl-maléimide</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Electrophoretic Mobility Shift Assay</term>
<term>Gene Deletion</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Bacterial</term>
<term>Gene Order</term>
<term>Metabolic Detoxication, Phase I</term>
<term>Operon</term>
<term>Protein Binding</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Analyse de profil d'expression de gènes</term>
<term>Délétion de gène</term>
<term>Détoxication de phase I</term>
<term>Liaison aux protéines</term>
<term>Opéron</term>
<term>Ordre des gènes</term>
<term>Régulation de l'expression des gènes bactériens</term>
<term>Test de retard de migration électrophorétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">NemR is an electrophile-sensing regulator which controls two enzymes required for the detoxification of reactive electrophiles: N-ethylmaleimide (NEM) reductase and glyoxalase I in Escherichia coli. Both enzymes are essential for bacterial survival in the presence of toxic reactive electrophiles, such as N-ethylmaleimide and methyl glyoxal. Here, we report the identification and characterization of NemR from Acinetobacter nosocomialis, a nosocomial pathogen. We confirmed that nemR and the nemA gene which encodes N-ethylmaleimide reductase form a single operon, which is in accordance with the reports from E. coli. Bioinformatic analysis revealed the presence of an NemR binding motif in the promoter regions of nemRA operon and gloA (encoding glyoxalase I) and the binding was confirmed by gel mobility shift assay. The deletion of nemR resulted in increased biofilm/pellicle formation in A. nosocomialis. mRNA expression analysis revealed that NemR acts as a repressor of the nemRA operon and gloA, and that the repressor function is inactivated by the addition of toxic Cys modification agents, contributing to bacterial survival. In addition, it was demonstrated that the nemRA operon is positively regulated by the quorum sensing regulator, AnoR and the operon plays a role in biofilm/pellicle formation in A. nosocomialis.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">30797834</PMID>
<DateCompleted>
<Year>2019</Year>
<Month>08</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised>
<Year>2019</Year>
<Month>08</Month>
<Day>27</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1769-7123</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>170</Volume>
<Issue>3</Issue>
<PubDate>
<MedlineDate>2019 Apr - May</MedlineDate>
</PubDate>
</JournalIssue>
<Title>Research in microbiology</Title>
<ISOAbbreviation>Res Microbiol</ISOAbbreviation>
</Journal>
<ArticleTitle>The transcription factor NemR is an electrophile-sensing regulator important for the detoxification of reactive electrophiles in Acinetobacter nosocomialis.</ArticleTitle>
<Pagination>
<MedlinePgn>123-130</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0923-2508(19)30017-8</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.resmic.2019.02.001</ELocationID>
<Abstract>
<AbstractText>NemR is an electrophile-sensing regulator which controls two enzymes required for the detoxification of reactive electrophiles: N-ethylmaleimide (NEM) reductase and glyoxalase I in Escherichia coli. Both enzymes are essential for bacterial survival in the presence of toxic reactive electrophiles, such as N-ethylmaleimide and methyl glyoxal. Here, we report the identification and characterization of NemR from Acinetobacter nosocomialis, a nosocomial pathogen. We confirmed that nemR and the nemA gene which encodes N-ethylmaleimide reductase form a single operon, which is in accordance with the reports from E. coli. Bioinformatic analysis revealed the presence of an NemR binding motif in the promoter regions of nemRA operon and gloA (encoding glyoxalase I) and the binding was confirmed by gel mobility shift assay. The deletion of nemR resulted in increased biofilm/pellicle formation in A. nosocomialis. mRNA expression analysis revealed that NemR acts as a repressor of the nemRA operon and gloA, and that the repressor function is inactivated by the addition of toxic Cys modification agents, contributing to bacterial survival. In addition, it was demonstrated that the nemRA operon is positively regulated by the quorum sensing regulator, AnoR and the operon plays a role in biofilm/pellicle formation in A. nosocomialis.</AbstractText>
<CopyrightInformation>Copyright © 2019 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Subhadra</LastName>
<ForeName>Bindu</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: bindu.subhadra@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Surendran</LastName>
<ForeName>Surya</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: tankz93@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Dong Ho</ForeName>
<Initials>DH</Initials>
<AffiliationInfo>
<Affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: casiopea1208@naver.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Woo</LastName>
<ForeName>Kyungho</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: khwoo1991@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Oh</LastName>
<ForeName>Man Hwan</ForeName>
<Initials>MH</Initials>
<AffiliationInfo>
<Affiliation>Department of Nanobiomedical Science, Dankook University, Cheonan, 31116, South Korea. Electronic address: yy1091@dankook.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Choi</LastName>
<ForeName>Chul Hee</ForeName>
<Initials>CH</Initials>
<AffiliationInfo>
<Affiliation>Department of Microbiology and Medical Science, Chungnam National University School of Medicine, Daejeon, 35015, South Korea. Electronic address: choich@cnu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2019</Year>
<Month>02</Month>
<Day>21</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>France</Country>
<MedlineTA>Res Microbiol</MedlineTA>
<NlmUniqueID>8907468</NlmUniqueID>
<ISSNLinking>0923-2508</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004269">DNA, Bacterial</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012097">Repressor Proteins</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>50NP6JJ975</RegistryNumber>
<NameOfSubstance UI="D006037">Glyoxal</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>O3C74ACM9V</RegistryNumber>
<NameOfSubstance UI="D005033">Ethylmaleimide</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000150" MajorTopicYN="N">Acinetobacter</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D004269" MajorTopicYN="N">DNA, Bacterial</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D024202" MajorTopicYN="N">Electrophoretic Mobility Shift Assay</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005033" MajorTopicYN="N">Ethylmaleimide</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D017353" MajorTopicYN="N">Gene Deletion</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D015964" MajorTopicYN="N">Gene Expression Regulation, Bacterial</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D023061" MajorTopicYN="N">Gene Order</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006037" MajorTopicYN="N">Glyoxal</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D050216" MajorTopicYN="N">Metabolic Detoxication, Phase I</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D009876" MajorTopicYN="N">Operon</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012097" MajorTopicYN="N">Repressor Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">A. nosocomialis</Keyword>
<Keyword MajorTopicYN="N">Bleach-sensing regulator</Keyword>
<Keyword MajorTopicYN="N">Methyl glyoxal</Keyword>
<Keyword MajorTopicYN="N">NEM</Keyword>
<Keyword MajorTopicYN="N">NemR</Keyword>
<Keyword MajorTopicYN="N">Reactive electrophile</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2018</Year>
<Month>11</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2019</Year>
<Month>02</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2019</Year>
<Month>02</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2019</Year>
<Month>2</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2019</Year>
<Month>8</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2019</Year>
<Month>2</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">30797834</ArticleId>
<ArticleId IdType="pii">S0923-2508(19)30017-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.resmic.2019.02.001</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Corée du Sud</li>
</country>
</list>
<tree>
<country name="Corée du Sud">
<noRegion>
<name sortKey="Subhadra, Bindu" sort="Subhadra, Bindu" uniqKey="Subhadra B" first="Bindu" last="Subhadra">Bindu Subhadra</name>
</noRegion>
<name sortKey="Choi, Chul Hee" sort="Choi, Chul Hee" uniqKey="Choi C" first="Chul Hee" last="Choi">Chul Hee Choi</name>
<name sortKey="Kim, Dong Ho" sort="Kim, Dong Ho" uniqKey="Kim D" first="Dong Ho" last="Kim">Dong Ho Kim</name>
<name sortKey="Oh, Man Hwan" sort="Oh, Man Hwan" uniqKey="Oh M" first="Man Hwan" last="Oh">Man Hwan Oh</name>
<name sortKey="Surendran, Surya" sort="Surendran, Surya" uniqKey="Surendran S" first="Surya" last="Surendran">Surya Surendran</name>
<name sortKey="Woo, Kyungho" sort="Woo, Kyungho" uniqKey="Woo K" first="Kyungho" last="Woo">Kyungho Woo</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/DetoxFungiV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000291 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000291 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    DetoxFungiV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30797834
   |texte=   The transcription factor NemR is an electrophile-sensing regulator important for the detoxification of reactive electrophiles in Acinetobacter nosocomialis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30797834" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a DetoxFungiV1 

Wicri

This area was generated with Dilib version V0.6.38.
Data generation: Fri Nov 20 16:09:04 2020. Site generation: Fri Nov 20 16:15:24 2020